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Table Of Content 5. Molecular Dynamic (MD) Simulation Computational Approaches in Drug Discovery and Design 8 Single-step Free Energy Perturbation (SSFEP) 2. Ligand Based Drug Design (LBDD) Like SARS and MERS, the genome of SARS-CoV-2 encodes sixteen nonstructural proteins (nsps) such as main protease (Mpro), papain-like protease, RNA-dependent RNA polymerase (RdRp), helicase etc., four structural proteins (envelope, membrane, spike, and nucleocapsid), and other accessory proteins. While the spike glycoprotein is essential for the interaction of the virus with the host cell receptor, the nsps play a major role during the virus life cycle by engaging in the production of subgenomic RNAs [13, 14]. The nonstructural and structural proteins, therefore, offer promising targets for the design and development of antiviral agents against COVID-19 [13]. The lack of effective vaccines or drugs for the treatment of COVID-19 and the high mortality rate necessitates the rapid discovery of novel
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Table Of Content The fine printMust-know information for guests at this property See what guests loved the most: What are the check-in and check-out times at Hyatt House Portland / Downtown? Top tips for your stay at Hyatt House Portland/Downtown Site search What type of room can I book at Hyatt House Portland / Downtown? EXPLORE NEARBY ATTRACTIONS, ACTIVITIES AND LOCAL EXPERIENCES About Hyatt House Portland/Downtown Hyatt House Portland / Downtown is set in the Riverplace district in Marquam Hill, 1.8 km from Portland and 14 km from Vancouver. Guests can enjoy the on-site restaurant and complimentary Wi-Fi.Studio rooms and one-bedroom suites offer fully equipped kitchens, separate living and sleeping spaces. The H BAR, features a selection of premium wines, cocktails and local Portland beers.Oregon Convention Center and Moda Center is 4 km from Hyatt House Portland / Downtown, while the Portland Art Museum is 2 km away. The nearest airport is Portland International Airport, 11 km
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